The Turnover Rate of Phospholipids in the Plasma of the Dog as Measured with Radioactive Phosphorus

نویسندگان

  • D. B. Zilversmit
  • C. Entenman
  • M. C. Fishler
  • I. L. Chaikoff
چکیده

1. A method for the determination of turnover time and turnover rate of plasma phospholipid is presented. 2. During the postabsorptive state 5.2 to 8.0 mg. of phospholipid phosphorus are turned over per hour in the plasma of dogs weighing 6-9 kilos. 3. The amount of phospholipid in an organ that is supplied by plasma phospholipid per hour is calculated.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Formation of Phospholipid by the Hepatecto- Mized Dog as Measured with Radioactive Phosphorus

Hevesy (1,Z) and Artom (3) have inferred from studies on the incorporation of labeled inorganic phosphate into phospholipid that plasma phospholipid is formed largely in the liver. This inference was based on a comparison of the specific activities of phospholipid phosphorus of plasma with those of other organs. Similar observations have been made in this laboratory (Table I). The phospholipid ...

متن کامل

Removal of plasma phospholipides as a function of the liver; the effect of exclusion of the liver on the turnover rate of plasma phospholipides as measured with radioactive phosphorus.

Although the reaction involving the incorporation of inorganic phosphate into phospholipides is not restricted to any one tissue (surviving slices of liver, kidney, brain, spinal cord, small intestine, and muscle (1) have been shown to effect this reaction), the phospholipides contained in plasma are synthesized mainly by the liver (2). This function of the liver in the formation of plasma phos...

متن کامل

O-16: Metabolism of Exogenous Fatty Acids, Fatty Acid-Mediated Cholesterol Efflux, PKA and PKC Pathways in Boar Sperm Acrosome Reaction

Background: For understanding the roles of fatty acids on the induction of acrosome reaction which occurs under association of cholesterol efflux and PKA or PKC pathways in boar spermatozoa, metabolic fate of alone and combined radiolabeled 14C-oleic acid and 3H-linoleic acid incorporated in the sperm was compared, and behavior of cholesterol and effects of PKA and PKC inhibitors upon fatty aci...

متن کامل

The effects of lipotropic factors on phospholipide turnover in the plasma of normal persons as indicated by radioactive phosphorus.

The action of choline and methionine in preventing or curing the fatty infiltration of the liver which is produced experimentally in animals by low protein diets is believed to result from an increased turnover of phospholipides in the liver (1, 2). Since this organ is the main, if not the sole, source of phospholipides in plasma (3), it would seem that changes in the formation of phospholipide...

متن کامل

Phospholipid Exchange Between Plasma and Erythrocytes in Man and the Dog CLAUDE

A B S T R A C r The turnover of the four major erythrocyte phospholipids has been studied with 32P, both in vivo and in vitro, in man and the dog. Phosphatidyl serine and phosphatidyl ethanolamine appeared to be stable erythrocyte lipids in both species. Turnover of the phosphate moiety of lecithin and sphingomyelin in the circulating erythrocytes of these two species seems entirely due to an e...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of General Physiology

دوره 26  شماره 

صفحات  -

تاریخ انتشار 1943